Özgül Konakçı, a 25-year-old who lives in Malatya, Turkey, said the aftershocks - and freezing weather - made things worse.
"It's very cold and it's snowing right now," she told BBC Turkish. "Everyone is on the streets, people are confused about what to do. Just before our eyes, the windows of a building exploded due to aftershocks."
As a second earthquake occurred at 10:24 GMT, a camera operator for Turkish news channel A Haber could be seen running from a collapsing building in Malatya as screaming was heard in the background.
"As we were heading to the rubble to [film] search and rescue efforts, there were two consecutive aftershocks with a loud noise," reporter Yuksel Akalan said on air.
"The building you are seeing on my left was brought down to earth. There is a lot of dust. A local resident is coming and he is covered in dust. A mother is taking her children [away]."
Ozgul Konacki, 25 and from Malatya, spoke while waiting outside with her family, having seen buildings around them collapse.
"Some people wanted to go back to their houses because it was too cold," she said. "But then we felt strong aftershocks and they were out again."
Ismail Al Abdullah - a rescuer from Syrian humanitarian group White Helmets - has been working in Sarmada, near the border with Turkey, rescuing survivors.
"Many buildings in different cities and villages in north-western Syria collapsed, destroyed by this earthquake," he said.
"We need help. We need the international community to do something, to help us, to support us. North-western Syria is now a disaster area. We need help from everyone to save our people."
Imogen James - BBC News